#1 pick at the "TopTenREVIEWS Gold Award" winner, SnagIt by TechSmith Corporation.

SnagIT version 8.2.0 includes:
Create Interactive Presentation Graphics
Bring Your Flash Videos into PowerPoint
Resize, Reshape and Rotate Callouts
Improved Add–Ins for Office, Firefox and COM
SnagIt Works With 64–Bit OS and IE 7
Apply the Same Effect to Multiple Areas of a Capture
Communicate Visually over Skype